백서에서 인간 탈회동결건조골 수화시간에 따른 초기 골치유
EFFECT OF HYDRATION TIME OF DEMINERALIZED FREEZE-DRIED BONE ON EARLY BONE REGENERATION IN OSSEOUS DEFECTS IN RATS
소속 상세정보
김상렬/Sang Ryul Kim
김수관/장현선/조세인/Su Gwan Kim/Hyun Seon Jang/Se In Cho
KMID : 0355620020280030188
Abstract
The purpose of this investigation was to evaluate the relationship between the hydration time of demineralized freeze-dried bone (DFDB) and early new bone formation in rat calvarial defects filled with DFDB.
Rats (n=43) were divided into 4 experimental groups. Standard, transosseous circular defects of the calvaria were made midparietally. In experimental group 1, the defect was grafted immediately after soaking the DFDB. In experimental group 2, the
defects were grafted with DFDB after soaking the DFDB for 10 minutes. In experimental groups 3 and 4, the defects were filled after soakingthe DFDB for 30 and 60 minutes, respectively. Graft sites were analyzed histologically after healing
periods
of 1,
2, or 4 weeks. Each group showed similar bone regeneration at each time point by histological analysis.
The results of this study were as followings:
1. After 1 week, a significant amount of inflammation, granulation tissue, and adema were found. A small amount of bone was seen, but the amount of bone did not differ between groups.
2. After 2 weeks, a small amount of new bone formation and DFDB resorprion were observed.
3. After 4 weeks, a greater amount of new bone formation was observed. The greatest amount of bone formation occurred in experimental group 4 after 4 weeks.
We conclude that the hydration time of DFDB does not affect new bone formation and that it is very important to control inflammation in bone grafting.
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